Here's a deadly brilliant "prank":
Take a sponge (make sure it is REAL, not synthetic) and soak it in a saturated starch solution. Squeeze it down into a small ball and tie it with a string around so it will keep its shape until it is completely dry.
Remove the string once it is dry. Have 2 bags of chemical; sodium cyanide and citric acid. Drop the sponge ball down the target's toilet, and push it down just out of sight using something like a coat hanger.
Pour the citric
acid in the bowl, and pour the cyanide in the water tank. Use enough of the chemicals to make sure it is a saturated solution for maximum effect. Don't use any other acids, you want to use citric because the odor/color won't give it away. Cyanide goes in the tank because it reacts with water and trace amounts of hydrogen cyanide can be detected if it wasn't sealed in the tank.
What happens basically is that the sponge expands to clog the toilet, and keeps the chemicals in bowl. When the target/victim flushes the toilet, the cyanide solution in the tank flows to the bowl where it reacts with the citric
acid and it forms Hydrogen Cyanide gas. The concentration will be immense enough that the victim will die instantly, and anyone else in the bathroom will die as well. Pretty much anyone who enters the bathroom will probably die as well.
Feel free to test this using vinegar and baking soda instead of the chemicals, and you can use a plunger instead a sponge too.
Pretty effective when done right, and if caution is properly taken near impossible to trace.